cobas b 221 operator manual

Report this Document Download Now Save Save Roche Cobas B221 - Service Manual For Later 100% (1) 100% found this document useful (1 vote) 648 views 368 pages Roche Cobas B221 - Service Manual Uploaded by Dian Zainal Abidin Description: OK Full description Save Save Roche Cobas B221 - Service Manual For Later 100% 100% found this document useful, Mark this document as useful 0% 0% found this document not useful, Mark this document as not useful Embed Share Print Download Now Jump to Page You are on page 1 of 368 Search inside document Browse Books Site Directory Site Language: English Change Language English Change Language. Systems with a serial number of 5001 or above are cobas b 221 systems. Systems with a serial number up to 5000 are Roche OMNI S systems. Every effort has been made to ensure that all the information contained in this manual is correct at the time of printing. However, Roche Diagnostics GmbH reserves the right to make any changes necessary without notice as part of ongoing product development. Any customer modification to the instrument will render the warranty or service agreement null and void. Software updates are done by Roche Service representatives. The user must be familiar with the function and operation of the instrument to fully understand the processes described here.The contents of this document may not be reproduced in any form or communicated to any third party without the prior written consent of Roche Diagnostics. Every effort is made to ensure its correctness. Subject to change without notice. Trademarks COBAS, COBAS B, LIFE NEEDS ANSWERS, ROCHE OMNI, AUTOQC, ROCHE MICROSAMPLER, COMBITROL, AUTO-TROL and COBAS BGE LINK are trademarks of Roche. The user must be familiar with the function and operation of the instrument to fully understand the processes described here.In addition, a complete index can be found at the end.

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Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. Sign in Forgot Password. My Bench Close Sign In Not A Member. Sign Up Join MedWrench OK name type Receive Summary Emails. The analyzer's analytical performance, the flexible configuration of parameters and features supported by its intuitive operation and zero maintenance sensors makes cobas b 221 system a valuable and easy to use tool for all Critical Care applications at the Point of Care (i.e. Intensive Care Unit, Emergency Room etc.) as well as in the laboratory. When equipped with an AutoQC module and connected to our data and instrument management IT solution, user interaction with the system can be reduced to an absolute minimum FORUMS View All (3) Ask a New Question 1 Reply -Ekenechukwu Ignatius 7 years ago 7 years ago Roche cobas b221 reagent pack size Reply 1 Reply -PSZ 7 years ago 7 years ago log in By continuing to browse the site you are agreeing to our use of cookies. Please review our Privacy Policy for more details. All Rights Reserved. Timely monitoring of critical newborns can reduce the risk of potentially life-threatening diseases and enhance neonatal care for hyperbilirubinemia.Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates. Discover everything Scribd has to offer, including books and audiobooks from major publishers. Start Free Trial Cancel anytime.

0 cobas b 221 system Brands COBAS, COBAS B, LIFE NEEDS ANSWERS, ROCHE OMNI, AUTOQC, Documents The universal system for Line Products FOB Gold Fecal. Hwever, Rche Diagnstics GmbH reserves the right t make any changes necessary withut ntice as part f nging prduct develpment. Any custmer mdificatin t the instrument will render the warranty r service agreement null and vid. Sftware updates are dne by Rche Service representatives. Cpyright 2009, Rche Diagnstics GmbH, all rights reserved The cntents f this dcument may nt be reprduced in any frm r cmmunicated t any third party withut the prir written cnsent f Rche Diagnstics. While every effrt is made t ensure its crrectness, Rche Diagnstics assumes n respnsibility fr errrs r missins which may appear in this dcument. Subject t change withut ntice. Instructins fr Use Revisin 4 cbas b 221 system Brands COBAS, COBAS B, LIFE NEEDS ANSWERS, ROCHE OMNI, AUTOQC, ROCHE MICROSAMPLER, COMBITROL and AUTO-TROL are trademarks f Rche. This manual has detailed descriptins f cbas b 221 system features and general peratinal cncepts, specificatin functins and use f cntrls, perating techniques, emergency prcedures, prduct labeling and maintenance prcedures. Hw t use this manual Keep this manual in a safe place t ensure that it is nt damaged and remains available fr use. This Instructins fr Use shuld be easily accessible at all times. T help yu find infrmatin quickly, there is a table f cntents at the beginning f the bk and each chapter. In additin, a cmplete index can be fund at the end. Where t find infrmatin In additin t the Instructins fr Use, the fllwing dcuments are als prvided t assist in finding desired infrmatin quickly: cbas b 221 system Reference Manual cbas b 221 system Shrt Instructin Cnventins used in this manual Visual cues are used t help lcate and interpret infrmatin in this manual quickly. This sectin explains frmatting cnventins used in this manual.

Where to Find Information In addition to the Service Manual, the following documents are also provided to assist in finding desired information quickly: o cobas b 221 system Instructions for Use o cobas b 221 system Operators CD o cobas b 221 system Reference Manual o cobas b 221 system Short Instruction o cobas b 221 system Service Manual (PDF or iSDoc version in GRIPS) o cobas b 221 system Spare Part List (PDF or iSDoc version in GRIPS) o Keep this manual in a safe place to ensure that it is not damaged and remains available for use.Roche Diagnostics May 2009 8 Service Manual Version 9.0 cobas b 221 system Conventions used in this manual Visual cues are used to help locate and interpret information in this manual quickly. This section explains formatting conventions used in this manual. Symbols The following symbols are used: e For more information about warning symbols, refer to the cobas b 221 system Intructions for Use. Biohazard Risk of infection. High Voltage Passages that are marked with this symbol warn of an immediate danger in connection with electrical wiring or components. ESD protection measures All sections or passages that are marked with this symbol warn of specific dangers in connection with static discharge. Packages that are marked with this symbol must only be opened by trained technical staff. Invisible Laser Radiation Avoid direct radiation to eyes Laser Class 3R according to EN 60825-1 P0 Recommended COBAS INTEGRA 400 plus - Roche Diagnostics (Schweiz) Direkt Kreatinin enzymatisch. Roche Elecsys, Cobas Abbott Architect, AxSym 17.05.2014 Documents cobas 8000 modular analyzer series Intelligent LabPower cobas 8000 modular analyzer series is the newest member of the Roche cobas modular platform family.. 6,000 5,000 8,000 7,000 9,000 050100 150200 250 300 Documents cobas b 221 system - Frank's Hospital Diagnostics April 2009 2 Instructions for Use Revision 10.

0 A-3 16 1 Safety infrmatin cbas b 221 system Cntents A-4 Instructins fr Use Revisin 10.0 17 cbas b 221 system 1 Safety infrmatin Imprtant infrmatin Imprtant infrmatin These Instructins fr Use cntain vital warnings and safety infrmatin. This instrument is intended t be used nly fr the specialized purpse described in the instructins. The mst imprtant prerequisites fr use, peratin, and safety are explained t ensure smth peratin. N warranty r liability claims will be cvered if the machine is used in ways ther than thse described r if the necessary prerequisites and safety measures are nt bserved. The instrument may be perated nly by persns whse qualificatins enable them t cmply with the safety measures that are necessary during peratin f the instrument. Suitable prtective equipment, like labratry clthing, prtective glves, prtective gggles and if necessary muth prtectrs, must be wrn t prevent direct cntact with bilgical wrking materials. In additin, a face mask is required if there is a risk. Adjustments and maintenance perfrmed with cvers remved and pwer cnnected may be attempted nly by a qualified technician wh is aware f the assciated dangers. Instrument repairs are t be perfrmed nly by the manufacturer r qualified service persnnel. Only accessries and supplies either delivered by r apprved by Rche are t be used with the instrument. These items are manufactured especially fr use with this instrument and meet the highest quality requirements. Operatin f the instrument with slutins whse cmpsitin is nt cnsistent with that f the riginal slutins can negatively affect the lng-term measurement accuracy. Deviatins in the cmpsitin f the slutins can als decrease the service life f the electrdes. In rder t ensure the quality f the measurement results, cmplete a quality cntrl test n 3 levels (lw, nrmal, high) after each electrde exchange, after each exchange f slutins and packs and after startup f the instrument.

Risk f infectin All sectins and parts f texts that are marked with this symbl describe prcedures that may invlve risk f infectin. IVD symbls The symbls are used in accrdance with DIN EN 980 (a) and DIN EN ISO 780 (b). Lt designatin Use by. The prduct shuld nt be used after expiry f the specified date. If a day is nt indicated, apply the last day f the respective mnth. Temperature limitatin The cnditins necessary t preserve the prduct's shelf life befre pening. Other symbls The fllwing symbls are listed as additinal infrmatin: Symbl Descriptin Electrdes: This date indicates the limit f the maximum strage time f an electrde. The electrde must be installed in the instrument n later than the imprinted date. If the installatin takes place n the imprinted date, it still falls within the specificatins. The calculatin f the Install befre date is based n the prductin date f the elctrde. Danger f sensitizatin during cntact with skin (when classified with R 43). Cautin: Avid cntact with eyes and skin, d nt inhale vaprs. Instructins fr Use Revisin 10 cbas b 221 system Symbl Descriptin Invisible Laser Radiatin Avid direct radiatin t eyes. Abbreviatins The fllwing abbreviatins are used: Abbreviatin A ANSI AQC B BG BUN C CLIA CLSI cnd CSA D dba DIL DNS E EC e.g. EN F FMS H Hct HIV HW Definitin American Natinal Standards Institute Autmatic Quality Cntrl Bld gas Abbr.This curve apprximates the audible range f the human ear. Instructins fr Use Revisin 12 cbas b 221 system 10 Instructins fr Use Revisin 10.0 13 Intrductin and specificatins A 1 Safety infrmatin A-3 2 General descriptins A-7 3 Installatin and shutdwn A-25 4 Specificatins A-57 5 Theretical fundatins A-95 14 15 cbas b 221 system 1 Safety infrmatin Cntents Safety infrmatin The infrmatin prvided in this chapter is essential fr the safe, truble-free peratin f the instrument and must be read and understd by the user. In this chapter Chapter 1 Imprtant infrmatin. 5 Operating safety infrmatin. 6 Instructins fr Use Revisin 10.

The ammnia ins can be determined using a ptentimetrical ammnia in-selective electrde. This measurement requires a reference electrde such as thse used in in-selective electrdes. Hematcrit: Measurement f the sample's cnductivity in the ISE measuring chamber. Calibratin prcedure thb and SO 2 was calibrated when the instrument was manufactured. Oxygen (O 2 ): PCO 2, ph, ISE: MSS: COOX: Ambient air and a zer pint slutin are used t calibrate xygen.Instructins fr Use Revisin 10.0 A-13 26 2 General descriptins cbas b 221 system Measurement evaluatin Measurement evaluatin The validity f the test results frm the cbas b 221 system must be carefully examined by a clinical-medical specialist wh will take the patient's clinical cnditin int cnsideratin befre any clinical decisins are reached based n the test results. The level have t be alternated (lw, nrmal, high).Safety instructins fr specific dangers Handling samples While handling samples, all necessary regulatins cncerning hygiene must be bserved. Dangerus pathgenic agents culd be present. Rche recmmends fllwing a decntaminatin prcedure in additin t regulatins specific t the labratry. These decntaminatin prcedures shuld be perfrmed peridically t minimize the risk f infectins. The temperature f the slutins shuld be adapted t the ambient temperature befre use. The shelf life f the slutins is limited. Please read the bttle label and the packaging fr the crrect strage temperature and the maximum shelf life. DO NOT FREEZE! If frzen, the slutin's cncentratin may change and cause calibratin errrs. D nt use damaged fluid packs (S2 and S3). D nt mix the individual cmpnents. Handling electrdes Stre the electrdes accrding t the packaging specificatins. The shelf life f the electrdes is limited. Please read the label and the packaging fr the crrect strage temperature and the maximum shelf life. CAUTION! Installatin nte fr the PCO 2 electrde Insert the electrde int the measuring chamber within 5 minutes f pening the ALU-PE packaging.

A special prtective gas atmsphere designed t cnditin the PCO 2 electrde during strage is fund inside the ALU-PE packaging. This gas atmsphere ensures immediate ptential stability during insertin f the electrde int the measuring chamber and immediate readiness fr measuring the first 2 pint calibratin. If mre than 5 minutes elapse after pening the ALU-PE packaging, the level f gas cnditining culd be lst and the time required fr the first-time calibratin culd be increased. Instructins fr Use Revisin 10.0 A-15 28 2 General descriptins cbas b 221 system General ntes n the use f the MSS cassette General ntes n the use f the MSS cassette Fr instrument versins with MSS mdule nly. Attentin: MSS cassette may nly be brught int cntact with liquids in the cbas b 221 system while electrdes are changed. Replace the MSS cassette within 28 days f installatin. After initial cntact with liquids, the MSS cassette may n lnger be remved frm the instrument. It may lead t the destructin f the enzyme sensrs. Strage: At 2 8 C, maximum f 2 weeks at rm temperature. MSS cassette remved frm the measuring chamber Once an MSS cassette is expsed t liquid, it must nt be allwed t dry ut under any circumstances since this wuld destry the enzymes. The enzymes are equipped with a special prtectant prir t shipping fr transprtatin purpses. This prtectant is washed ut inside the instrument during the warm-up phase and MSS plarizatin. Incmpatible substances The fllwing substances may nt be intrduced int the MSS measuring chamber under any circumstances since they wuld immediately destry the MSS sensrs r severely impact their functinality. A-16 Instructins fr Use Revisin 10.0 29 cbas b 221 system 2 General descriptins General ntes n the use f the MSS cassette Inserting the MSS cassette Hld the MSS cassette nly at the designated handle and avid tuching the cntacts.All infrmatin (results, errr messages, alarms, warnings, etc.) is displayed n the screen.

Additinally cmplete a quality cntrl test n ne level between tw autmatic 2P calibratins. The level have t be alternated (lw, nrmal, high). Since the measurements f the instrument depend nt nly n the crrect characteristic functin, but als n a series f marginal cnditins (e.g. pre-analysis), results btained frm the instrument shuld be submitted fr an expert pinin befre taking additinal measures based n the supplied measurements. Cautin (refer t accmpanying dcuments). Please refer t safety-related ntes in the manual accmpanying this instrument. In rder t preserve this cnditin and ensure safe peratin, the user must respect the ntices and warnings that are cntained in these Instructins fr Use. The instrument meets the cnditins fr cntaminatin level 2. D nt perate the instrument in an explsive envirnment r in the vicinity f explsive anesthetic mixtures cntaining xygen r nitrus xide. If bjects r liquids enter the internal areas f the instrument, remve the instrument frm its pwer supply and allw an expert t check it thrughly befre using it again. The instrument is suitable fr lng-term peratin indrs. The pwer crd must be plugged int a grunded pwer receptacle. When using an extensin crd, make sure it is prperly grunded. Any rupture f the grund lead inside r utside the instrument r a lse grund cnnectin may result in hazardus perating cnditins fr the perating persnnel. Intentinal discnnectin f the grunding is nt permitted. The instrument is nt suitable fr peratin with a direct current pwer supply. Use nly the riginal pwer plug delivered with the cbas b 221 system. The use f cntrls r adjustments r perfrmance f prcedures ther than thse specified herein may result in hazardus radiatin expsure. A-6 Instructins fr Use Revisin 10.0 19 cbas b 221 system 2 General descriptins Cntents General descriptins This chapter cntains a general descriptin f the instrument, as well as precautinary measures against special dangers and the prper handling f sensrs, slutins and the MSS cassette.

Instructins fr Use Revisin 10.0 A-9 22 2 General descriptins cbas b 221 system Intrductin During the measurement r calibratin r ther prcesses, it is pssible t cnduct database peratins, perfrm certain settings r call up general infrmatin at the same time.In rder t achieve accurate measurements f recmmended aqueus cntrl slutins (with regards t deviatins frm bilgical samples), chse the prper cmpnents and make the crrespnding crrectins in the QC measurement mde. Operating instructins The cbas b 221 system shuld be switched n at all times. If the instrument is switched ff fr an extended perid f time (mre than 24 hurs), a shutdwn must be perfrmed.Prevent any ther liquids frm entering the instrument except samples and QC material at the fill prt. The level have t be alternated (lw, nrmal, high).With Sftware V 6.0 nwards, using cbas bge link, the instrument can be mnitred frm ne lcatin, any disturbances can be remedied and the analytical quality mnitred.In rder t prevent multiple peratin f the instrument, n buttns n the screen shuld be pressed. A-12 Instructins fr Use Revisin 10.0 25 cbas b 221 system 2 General descriptins Measurement and calibratin prcedure Measurement and calibratin prcedure Measurement prcedure PO 2: Use f the Clark measurement principle: measurement f current generated by the reductin f xygen. The ptassium and calcium membranes cntain special neutral carriers. A special in exchanger is used fr chlride membranes. Calculatin f these variables als requires the use f a reference electrde a permanently cntacted chlride electrde in the cbas b 221 system. Glucse, lactate: Glucse xidizes t frm glucnlactn using atmspheric xygen and the glucse-xidase (GOD) enzyme, lactate xidizes t frm pyruvate using the lactate xidase enzyme. Urea: Urea is brken int ammnia and carbn dixide thrugh urease. Ammnia and carbn dixide react thrugh hydrlysis with physilgical ph t frm ammnia r bicarbnate ins.

The electrdes are flw-thrugh electrdes with a visible sample channel. Instructins fr Use Revisin 10.0 A-19 32 2 General descriptins cbas b 221 system System descriptin COOX mdule The COOX mdule cnsists f the hemlyzer and the COOX measuring chamber. The measurement is based n the principle f spectral phtmetry. Pumps Depending n the cnfiguratin, up t three peristaltic pumps transprt the sample and the perating fluids inside the instrument. A-20 Instructins fr Use Revisin 10.0 33 cbas b 221 system 2 General descriptins System descriptin Reverse side E A D B C A B C Pwer supply Main pwer switch and cnnectr Warning and identificatin labels D E Air filter Interfaces Figure A-5 Reverse side Pwer supply This unit als cntains the main pwer switch and the cnnectr. A B C D E F A Pwer supply B Service cnnectr C RS 232 D Ext. A-22 Instructins fr Use Revisin 10.0 35 cbas b 221 system 2 General descriptins System descriptin Barcde scanner Figure A-9 Barcde scanner Scanning f electrde data (type, lt, expiratin date) Scanning f patient r user identity Scanning f QC data (QC material, lt, basis, expiratin date, target values, etc.) Scanning f desired alphanumeric cde Press the buttn n the underside t activate the scanner. A beeping sund and a brief illuminatin f the LED n the upper side indicate the successful scanning f the barcde. Fr mre detailed infrmatin, please see enclsed manual f the PS2 hand-held scanner (included in scpe f delivery). Instructins fr Use Revisin 10.0 A-23 36 2 General descriptins cbas b 221 system System descriptin Warning and identificatin labels (incl. The sequence f the steps described must be strictly fllwed. When installing an instrument that was stred in a cl rm r was transprted at lw temperatures, be aware that cndensatin may have frmed and culd cause disturbances t the instrument. The instrument must be climatized at rm temperature fr at least ne hur befre beginning peratin. A-30 Instructins fr Use Revisin 10.

0 43 cbas b 221 system 3 Installatin and shutdwn Installatin 2. Pwer supply 1 Place the pwer supply, including the tw adapter cnnectrs, n the hlder and psitin them. A B B A Screw B Hlder Figure A-14 Pwer supply 2 Tighten the screw. 3. Attach pwer crd and barcde scanner 1 Cnnect the pwer crd. 2 Cnnect the barcde scanner, and, if necessary, the netwrk cnnectin t the apprpriate prt n the rear side f the cbas b 221 system. 4. Switch n Switch the instrument n and wait until the prgram has cmpletely laded and started. Befre starting the installatin, yu must set the language, in which the unit is t be perated, the date and the time. Instructins fr Use Revisin 10.0 A-31 44 3 Installatin and shutdwn cbas b 221 system Installatin 5. Installatin When carrying ut the installatin, fllw the n-screen instructins. Installatin must be carried ut cmpletely and may nt be interrupted. Observe the listed sequence while perfrming the actins. If the autmatic first installatin is unsuccessful, yu must carry ut the installatin prcess manually.The time scale uses markers t shw the selected interval fr the 2P calibratin and the start time fr the system calibratin. Intervals: System calibratin 2P calibratin 1P calibratin Every 8, 12 r 24 hurs. Every 4, 8 r 12 hurs. This actin is perfrmed autmatically. Valve V19 is pushed in t prevent the tube frm being pinched while the aluminum part is tightened. A B A VM B V19 Figure A-18 Valve VM 3 Clse dcking mechanism and bttle cmpartment cver. A-34 Instructins fr Use Revisin 10.0 47 cbas b 221 system 3 Installatin and shutdwn Installatin 12. D nt bend the insert needle during this prcess. A A Needle Figure A-19 Insert needle 5 Rtate the fill prt 90 clckwise and upwards until it snaps int place.Check the crrect psitining f the sample inlet path t the bypass nipple (see belw). A-36 Instructins fr Use Revisin 10.0 49 cbas b 221 system 3 Installatin and shutdwn Installatin 13. Insert printer paper The printer paper is heat sensitive n ne side nly.

Observe the crrect insertin f the thermal paper rll. A B A Paper lid B Printer lever Figure A-25 Insert printer paper - withut take-up unit Figure A-26 Insert printer paper - with take-up unit (ptinal) 6 The paper is autmatically pulled int the printer. 7 Clse paper lid. With take-up unit (ptinal) 1 Press the paper feed buttn until the paper is lng enugh. 2 Insert the beginning f the paper in the take-up unit accrding t the instructins n the inside f the paper lid.During peratin, the paper shuld be tautened nw and then by turning the take-up rller. 3 Clse printer cver. A-38 Instructins fr Use Revisin 10.0 51 cbas b 221 system 3 Installatin and shutdwn Installatin 14. Insert peristaltic pump tubes 1 Open the peristaltic pump's clear plastic cver (tensin lever). 2 Push the linear bracket (white plastic part) upwards (see belw). Instructins fr Use Revisin 10.0 A-39 52 3 Installatin and shutdwn cbas b 221 system Installatin 16. Open the AutQC drawer and remve the AutQC valve clamp 1 Pull ut the AutQC drawer. 2 Pull the key f the AutQC valve up and ut (see belw). This actin is perfrmed autmatically. 18. Open AutQC drawer and insert ampule hlder 1 Pull the AutQC drawer ut again. In each case, pen nly the relevant measuring chamber. Keep the bttle cmpartment cver clsed. A-40 Instructins fr Use Revisin 10.0 53 cbas b 221 system 3 Installatin and shutdwn Installatin The fllwing screen appears: Figure A-31 Changing f electrdes 2 Open the lcking lever.Check the internal electrlyte f the electrdes fr pssible air bubbles (see belw). If there are air bubbles between the cntact pin and the membrane, there will nt be effective electrical cnductin. Result: calibratin and measurement errrs! 4 Remve any air bubbles. Remve air bubbles by hlding the electrde vertically and by tapping lightly with a fingernail against the electrde bdy (see belw). A A Free f air bubbles. Figure A-32 Electrde 5 Insert the electrdes, beginning at the right and prceeding left accrding t the clr cde.

6 Push all electrdes slightly t the right s that they are lined up tgether withut gaps. Instructins fr Use Revisin 10.0 A-41 54 3 Installatin and shutdwn cbas b 221 system Installatin a Insertin f the reference electrde 1 Insert the reference electrde. Figure A-33 Reference electrde 2 Insert the reference tube int the upper tube guide channel f the left lcking lever and int the tube hlder f the cver hinge. Clse the lcking lever (see belw). A A Lcking lever Figure A-34 Insertin f the reference electrde 3 Cnnect the white cnnectr n the end f the tube t the measuring chamber cassette (see belw). A B A Cnnectr B Measuring chamber cassette Figure A-35 Insertin f the reference electrde 2 4 Scan the barcdes lcated n the inner packaging f each electrde r enter the barcdes manually with the help f the keybard. 5 Clse the measuring chamber cver. A-42 Instructins fr Use Revisin 10.0 55 cbas b 221 system 3 Installatin and shutdwn Installatin a MSS measuring chamber (fr instrument versins with MSS mdule nly) Hld the MSS cassette nly at the designated handle and avid tuching the cntacts. 1 Open the cver f the MSS measuring chamber (apply frce t the right edge f the MC cver with a finger t push it t the left and pen up the MC cver). Having cmpleted the installatin prcess, the unit requests a bld sample. Remve packs rubber sealings. 4 Push the tw packs int the apprpriate lcatin in accrdance with the labeling n the dcking mechanisms until the packs lck. T avid splashing the S1 Rinse Slutin, deaerate the bttle at abut 3000 m abve sea level r higher befre inserting it. 6 Place the bttle tl n the screw cap f the S1 Rinse Slutin (see belw). A B Figure A-41 Open bttle Instructins fr Use Revisin 10.0 A-45 58 3 Installatin and shutdwn cbas b 221 system Installatin 21. Autmatic sequences take place and the unit warms up. 2 Installatin is cmplete. If a pwer failure ccurs during installatin, the installatin starts anew with the next restart.

Actins which were perfrmed successfully are discarded. 22. Perfrm MSS plarizatin (cbas b 221 system and cbas b 221 system nly) 1 Prepare a syringe r capillary with whle bld fr plarizatin. Figure A-42 MSS plarizatin 2 The bld sample is inserted via fill prt similar t a measurement.A-46 Instructins fr Use Revisin 10.0 59 cbas b 221 system 3 Installatin and shutdwn Installatin 23. A wrng barmeter value leads t wrng PO 2 measurement results. Quality cntrl 1 Define the material and if an AutQC drawer (ptin) is available insert the mats befre perfrming a quality cntrl measurement.Make sure that the results agree with the target values. Fllw the instructins n the screen. If the instrument is turned n again, a new MSS cassette must be inserted.Lnger than 24 hurs If the cbas b 221 system will be shut dwn fr lnger than 24 hurs, perfrm the fllwing prcedure. Befre perfrming a shutdwn, Rche Diagnstics recmmends decntaminating all surfaces and tube paths. The prcedure ends in switching ff the instrument. Prcessing the actins: Manual: Autmatic: The crrespnding line f the list bx cntains an instructin which must be perfrmed manually. A-48 Instructins fr Use Revisin 10.0 61 cbas b 221 system 3 Installatin and shutdwn Shutdwn Upn successful cmpletin, this symbl is displayed. 1. Open bttle cmpartment cver and nly remve bttle S1 and packs (depending n the cnfiguratin S2 and S3). 1 Open bttle cmpartment cver and dcking mechanism and remve bttle S1 and the packs (S2 and S3). D nt remve the waste cntainer! 2 Clse dcking mechanism and bttle cmpartment cver. 2. Fill the shutdwn kit with distilled water Fill the shutdwn kit abut halfway with distilled water. D nt bend the needle. Bth valves are pushed ut. 14. Release screws at V19 (bttle cmpartment) 1 Open the bttle cmpartment cver and the dcking mechanism S3. 2 Lsen the screws (A) f the aluminum part f valve V19 (apprx. 2-3 turns). A A V 19 A Screws Figure A-50 Valve V19 3 Clse the dcking mechanism S3 and the bttle cmpartment cver. 15.

cobas b 121 operator manual

Our online medical directory helps to reduce a time for searching for medical devices on the Internet to buy required equipment at a reasonable price from first-rate sellers and dealers of quality medical equipment. Everything is clear in the catalog and it will not cause any difficulties to find the particular medical device to purchase. At our website, there is a wide database of diseases and one of the biggest distributors databases on the Internet. This online catalog contains information about medical equipment from various suppliers, sellers, providers and manufacturers all over the world for every person to get in touch with a needed company to find out a cost for a required equipment and its availability for sale in a particular world region. Equipment, used in different stages of medical care, is grouped in categories according to disciplines and conveniently presented. Thus, our online catalogue is chosen by many medical professionals worldwide. Pharmaceutical market place. We are happy to provide our clients with an opportunity to find needed medical equipment online and choose a rich assortment of devices. We can help you get in touch with our partners and guarantee you a favourable deal on cobas b system at competitive prices. If you wish to make a purchase order to our suppliers and get cobas b system as well as other products for sale, let us help you. Instead of searching, where to buy cobas b system or how much it costs, write us and we will do everything to provide you with advanced medical equipment from our reputable manufacturers. Related products. Cranes Pharmaceutical market place. Address Deviceinformed. Savickio st. Sign up for our mailing list to get latest updates and offers. Copyright Deviceinformed. Powered by: itsolutions.Page of 93 Go. Quick Links. Download this manual. Host Interface Manual. Table of Contents. Page 5 cobas c Host Interface Manual 7. Published by Roche Diagnostics, a division of F.

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Discover everything Scribd has to offer, including books and audiobooks from major publishers. Start Free Trial Cancel anytime.Browse Books Site Directory Site Language: English Change Language English Change Language. You can make a request for the operating manual by completing the adjoining form. Subsequently, you will receive the operating manual as pdf-file. Visit our Shop Request a PDF Therefore, you will receive offers and information about relevant topics by e-mail or post. You can unsubscribe from this notification at any time. Timely monitoring of critical newborns can reduce the risk of potentially life-threatening diseases and enhance neonatal care for hyperbilirubinemia.Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates. Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. My Bench Close Not a Member.You can adjust your Community Subscriptions in Settings Continue Removed. Features of cobas b 121 Looking for New or Used Equipment. Shop on LabX Shop on Labx.com This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Please review our Privacy Policy for more details. All Rights Reserved. My Bench Close Not a Member.You can adjust your Community Subscriptions in Settings Continue Removed. Features of cobas b 121 Looking for New or Used Equipment. Shop on LabX Shop on Labx.com This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Please review our Privacy Policy for more details. All Rights Reserved. This online medical catalog of advanced medical tools and gadgets is a useful resource for doctors, nurses, paramedics, medical and nursing students, and also for scientists from various medical fields.

Learn More About This Seller. Tips for Buying this Device. Manufacturer Specifications. Request Alert. Add to My Favorites. Email this Page. Required Quantity. Please select your choice. Cancel Continue. Global online marketplace for buying and selling used medical equipment and medical equipment parts.Introduction: The introduction of a new method or new analyser is a common occurrence in clinical biochemistry laboratory. Correlation coefficient was calculated from the results obtained from both the analysers. Precision was calculated by running biorad ABG control samples. Results: The correlation coefficient values obtained for parameters were close to 1. Validation is associated with ensuring and checking that the product complies with set requirements and satisfies certain defined criteria. The introduction of a new method or new instrument in addition to the existing instruments is a common occurrence in clinical biochemistry laboratory. The semi-automated analysers are replaced by completely automated analysers to minimize analytical errors and to improve the turnaround time. Blood gas measurements and electrolytes are often performed in Point-Of-Care POC settings as well as larger clinical laboratories. Even a slight error in reporting ABG and electrolytes can have serious adverse effects on patient management especially critically ill patients. When a new POC analyser is obtained, the performance of the analyser should be validated. Both the ABG analysers Cobas b and rapid lab — Siemens were based on the principle of ion selective electrode method. Cobas b is a ABG analyser which can measure parameters which are critical for decision making. The sample volume required is 60 micro liters and the results are available within 50 seconds. The operator intervention is least and most of the analyser operations are automated. The study was a comparative study.

Hoffmann-La Roche; Basel, Switzerland. Cobas B 121 Other countries: The above trademarks are either owned by or used under license by the Roche affiliate distributing this product. About this manual This document details the specifications for the cobas c host interface HIF. Rerunning an order means to repeat according to the settings given in the application configuration, such as predefined dilution factors. The sample number is given by the operator while placing the sample on the system. LIS Interface configuration 5. Page 15 cobas c Host Interface Manual The analyzer will send inquiries for test and rerun orders only when this function is enabled. Note: Automatic result upload is only supported in Real-Time Communication mode. Version 2. Pin Sig. Page 19 cobas c Host Interface Manual Figure 4 if you intend to work with the software handshake or without any handshake.Log In for more options. Contact the Seller. Item Description. Questions and Answers Regarding this Item. Question Answer General: Did the device perform according to manufacturer specifications just before dismantling? Awaiting Confirmation General: Are there any visual or non visual damages? Awaiting Confirmation General: What is the date of refurbishing. Awaiting Confirmation General: What is the estimated size of the needed package. Awaiting Confirmation. Payment methods: Bank Transfer, Cash. The item is not packed. Seller allows inspection of item? All item information on this page has been supplied by seller and MedWOW cannot guarantee its accuracy. Post a Buying Request. A buying lead is an excellent way to reach worldwide medical equipment sellers. Rapidlab - Siemens. Cobas b - Roche Diagnostics. ABL - Radiometer. ABL77 Series - Radiometer. Stat Profile 5 - Nova Biomedical. Gem Premier - Mallinckrodt Puritan Bennett. Roche Cobas C111 Manual Ecosys II - Eschweiler. View All Blood Gas Analyzer devices for sale. Location: United Kingdom, London. Business type: Broker.

Our policy on cookies and other tracking technologies. This website uses cookies and other technologies to personalize content and advertisements on sites such as Google Ads, Facebook to you on this and other websites and provide social media features on this website, including social media sites such as Facebook, Twitter, LinkedIn. You can always update these settings in your browser if you change your mind. Privacy Policy.Systems with a serial number of or above are cobas b systems. Every effort has been made to ensure that all the information contained in this manual is correct at the time of printing. Any customer modification to the instrument will render the warranty or service agreement null and void. While every effort is made to ensure its correctness, Roche Diagnostics assumes no responsibility for errors or omissions which may appear in this document. Subject to change without notice. This manual has detailed descriptions of cobas b system features and general operational concepts, specification functions and use of controls, operating techniques, emergency procedures, product labeling and maintenance procedures. To help you find information quickly, there is a table of contents at the beginning of the book and each chapter. In addition, a complete index can be found at the end. Where to find information In addition to the Instructions for Use, the following documents are also provided to assist in finding desired information quickly: o cobas b system Reference Manual o cobas b system Short Instruction Conventions used in this manual Visual cues are used to help locate and interpret information in this manual quickly. Risk of infection All sections and parts of texts that are marked with this symbol describe procedures that may involve risk of infection. Lot designation Use by The product should not be used after expiry of the specified date. If a day is not indicated, apply the last day of the respective month.

Only the ABG samples that were sent to laboratory in heparinized syringes and ice packs were included in the study. Only those samples which were received by the laboratory within 10 mins of sample collection were included in the study. Under aseptic precautions, 2 ml of ABG sample were collected in heparinized syringes from radial artery.The cobas analyzer series is a member of the cobas modular platform. Roche Cobas C111 Manual It offers medium workload laboratories tailormade solutions for clinical chemistry and immunochemistry testing. Control Unit: PC, monitor, keyboard, printer, etc. Up to channels, in total 63 channels including ISE, automatic setting on cobas c module 25 channels on cobas e module. Primary tubes: 5 to 10 mL; 16 x16 x 75, 13 x13 x 75 mm Sample cup: 2. Start-up, Re-calibration For photometric modules: Linear, non-linear multi-points, 2 point calibration, K-factor up to different calibrators pre programmable Storage of up to curves Preventive calibration of the stand-by cobas c and cobas e packs on cobas c Two k-factor can be defined for different sample types. Last update on 2-OCT Toggle navigation. Products Cobas Available for cobas c and cobas e module. Via specified racks through the input buffer or STAT port.The operator-friendly system offers easy handling and requires no preventative maintenance, reducing analyzer downtime. Please disable any ad blockers and view the site in non-private mode. Allowing you to focus on patient critical care The cobas b POC system is a mobile, cartridge-based, critical care analyzer designed for POC testing. View Full Table. Assay menu View full List. Assay menu. Featured Product. New Product. Homocysteine enzymatic. Clinical Chemistry - Enzymes Portfolio. Roche Troponin T-high sensitive. Clinical Chemistry - Specific Protein Portfolio. Clinical Chemistry - Substrates Portfolio. Clinical Chemistry - Calibrators and Controls. Modal Title. Some randomr randomr randomr randomr randomr randomr.

Temperature limitation The conditions necessary to preserve the product's shelf life before opening. The electrode must be installed in the instrument no later than the imprinted date. If the installation takes place on the imprinted date, it still falls within the specifications.A-3 2 General descriptions.

cobas ampliprep manual

Please be aware that we do not take any responsibility for accessing such information, which may not comply with any valid legal process, regulation, registration or usage in New Zealand. If you require further information concerning a product listed on this site, please contact your local Roche Diagnostics New Zealand representative.”. Manual steps are limited to placing the samples and reagents to the instrument. This avoids any error which may occur in case of manual preparation. Efficiency and reliability of the results is further enhanced through the system for the detection of sample (Clot Detection). The correlation and concordance of results between the two assays were calculated. Further attention must be paid to those cases in which measured viral loads present larger differences between the two assays. Citing articles Article Metrics View article metrics About ScienceDirect Remote access Shopping cart Advertise Contact and support Terms and conditions Privacy policy We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. In a 24-h laboratory, this system can analyze 399 samples on one automated docked platform. Precision (within-run analysis) and linearity using regression analysis for the CAP-CTM HIV-1 v2.0 were measured on a specially prepared pooled plasma sample which was further divided into six aliquots. Seventy-five samples generated a “target not detected” result on any of the three real-time assays (a reflection of successful antiretroviral treatment at the clinic). The clinical impact of this improved sensitivity for patients being monitored on antiretroviral treatment programs remains to be determined. The variability of this difference (SD), however, is acceptable and shows good precision (reflected by a smaller distance between the limits of agreement) and overall good performance compared to the Abbott RealTi m e HIV-1. The application of this new CAP-CTM HIV-1 v.

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It has been the driving principle of our pioneering work in viral load monitoring since 1996. You can have confidence to stand behind — and take pride in — your work. When that happens, we have made a difference. Flexibility means the system can expand and adapt to your workflow and operational changes. From docked instrumentation to linked format, small to large volume workflow, batch or continuous loading mode, the system makes viral load monitoring practical for every lab. Designed to reduce hands-on time and further improve laboratory efficiency, the state-of-the-art cobas p 630 instrument improves your laboratory’s productivity while also providing the security that only comes from robotic assurance. Please be aware that we do not take any responsibility for accessing those information which may not comply with any legal process, regulation, registration or usage in the country of your origin. Please also be aware that the information in this website should not be used to diagnose, treat, cure or prevent any disease without the advice of a qualified medical professional, and does not replace medical advice or a medical examination.Please be aware that we do not take any responsibility for accessing those information which may not comply with any legal process, regulation, registration or usage in the country of your origin. Please also be aware that the information in this website should not be used to diagnose, treat, cure or prevent any disease without the advice of a qualified medical professional, and does not replace medical advice or a medical examination. Information on such websites is intended for a wide range of audiences. Some products described may not be licensed in accordance with New Zealand Medical Devices Regulations and therefore may not be available for sale in New Zealand.

Numerous new direct-acting antiviral (DAA) drugs and host-targeted agents (HTA) that block the HCV life cycle have reached early to late clinical development. With these new therapies, HCV RNA level monitoring is and will remain the most useful parameter to assess treatment responses and guide treatment decisions. HCV genotype 4 is currently increasing in incidence and prevalence in the intravenous drug user community in Western Europe and many industrialized areas ( 16, 17 ). It now represents approximately 10% of cases in France ( 17 ). HCV genotype 4 infection is difficult to treat and thus an important target of new HCV drug development. Therefore, accurate detection and quantification of HCV genotype 4 RNA is mandated in clinical trials with new HCV therapies and in clinical practice. MATERIALS AND METHODS Clinical specimens. Plasma and serum samples were obtained from patients infected with HCV genotype 4 referred to our Hepatology Reference Center with a diagnosis of chronic HCV infection and tested in our laboratory or diagnosed with HCV infection at the Cerba laboratory. Residual samples were used, and the patients gave their consent to their use. Group A comprised 122 patients with chronic HCV genotype 4 infection, all with detectable anti-HCV antibodies and HCV RNA. All samples were collected in 2011 and 2012. The genotype and subtype were determined by means of the reference method, i.e., sequencing of nonstructural 5B region of the HCV genome, followed by phylogenetic analysis, as previously described ( 18 ). Group A comprised 43 patients with subtype 4a, 4 with subtype 4c, 34 with subtype 4d, 9 with subtype 4e, 9 with subtype 4f, 2 with subtype 4g, 5 with subtype 4h, 4 with subtype 4k, 1 with subtype 4n, 8 with subtype 4r, and 3 with subtype 4t. Group B comprised 2 patients with subtype 4h, 1 with subtype 4l, and 1 with subtype 4k.

2 on the fully automated CAP-CTM 96 docked platform has potential for HIV VL monitoring in high-throughput settings. Although not investigated in this study, the CAP-CTM HIV-1 v2.0 also has the capability of detecting HIV group O per the manufacturer's instructions but requires further field evaluation for HIV-1 subtypes other than subtype C. The six lines shown represent the six replicates. The SD and %CV on the log values are represented for each dilution as well as the %CV for the absolute VL values. The equation of the line is also represented on the plot. The symbol keys indicate the assays for each plotted point. This publication was made possible by the generous support of the American people through the U.S. Agency for International Development.Lancet i: 307 -310. OpenUrl CrossRef PubMed Web of Science 3. ? Brambilla, D., S. Granger, and J. Bremer. Nucleic Acids Res. 35: e101. OpenUrl CrossRef PubMed 5. ? Kwok, S., and J. J. Sninsky. American Society for Microbiology, Washington, DC. 6. ? Oliver, A. R., S. F. Pereira, and D. A. Clark. Virus Genes 26: 151 -163. OpenUrl CrossRef PubMed Web of Science 8. ? Roche Molecular Systems. Cytometry 54B: 46 -53. OpenUrl PubMed NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses. NW Washington, DC 20036 Phone: (202) 737-3600. This article has been cited by other articles in PMC. Abstract Accurate hepatitis C virus (HCV) RNA quantification is mandatory for the management of chronic hepatitis C therapy. INTRODUCTION Accurate hepatitis C virus (HCV) RNA quantification is mandatory for the management of chronic hepatitis C therapy. Futility rules have been established in order to prevent unnecessary exposure to the protease inhibitor and to avoid adverse events, the emergence of viral resistance, and useless costs.

Since accurate quantification regardless of the HCV genotype is required in clinical practice, the manufacturer developed a new version (v2.0) of its TaqMan assay. The third-generation bDNA assay can be used as a reference method because of its accuracy and the lack of influence of the HCV genotype on quantification, due to the use of a large number of hybridization probes without the need for prior PCR amplification. This is not surprising, because different assays often have slight differences in their calibration in spite of the use of the World Health Organization standard, with no impact in clinical practice. European Association for the Study of the LiverGhany MG, Nelson DR, Strader DB, Thomas DL, Seeff LB.Hepatology. Chevaliez S, Rodriguez C, Pawlotsky JM.Gastroenterology. Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, Burroughs M, Brass CA, Albrecht JK, Esteban R.Fried MW, Hadziyannis SJ, Shiffman ML, Messinger D, Zeuzem S.Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, George J, Rizzetto M, Shouval D, Sola R, Terg RA, Yoshida EM, Adda N, Bengtsson L, Sankoh AJ, Kieffer TL, George S, Kauffman RS, Zeuzem S.Poordad F, McCone J, Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP.Jacobson IM, Bartels DJ, Gritz L, Kieffer TL, De Meyer S, Tomaka F, Bengtsson L, Luo D, Adiwijaya BS, Kauffman RS, Picchio G, Adda N.Jacobson IM, Marcellin P, Zeuzem S, Sulkowski MS, Esteban R, Poordad F, Bruno S, Burroughs MH, Pedicone LD, Boparai N, Deng W, Dinubile MJ, Gottesdiener KM, Brass CA, Albrecht JK, Bronowicki JP.Sarrazin C, Hezode C, Zeuzem S, Pawlotsky JM.Akhavan S, Ronsin C, Laperche S, Thibault V.Hepatology. Chevaliez S, Bouvier-Alias M, Brillet R, Pawlotsky JM.Hepatology. Chevaliez S, Bouvier-Alias M, Castera L, Pawlotsky JM.

The Cobas TaqMan 96 analyzer was used for automated real-time PCR amplification and detection of PCR products according to the manufacturer's instructions. Statistical analysis. Relationships between quantitative variables were studied by means of regression analysis. For this, we used Deming regression, a statistical method for comparing non-gold-standard laboratory methods that takes measurement errors for both methods into account. For better visualization of differences between the quantification assays, we also used the Bland-Altman plot method, in which the differences between the two techniques are plotted against the averages of the two techniques. P values of RESULTS HCV RNA quantification accuracy and influence of the HCV subtype. This figure includes Deming regressions and Bland-Altman representations for pairwise comparisons of the assays. In the Deming regression figures, the dashed line is the identity line; the black line surrounded by two dashed lines shows the Deming fit and 95% confidence interval, respectively. Only subtypes with more than five samples are represented. The midline and lower and upper edges of the boxes represent the median value, 25th percentile, and 75th percentile, respectively. The lower and upper error bars represent the 10th and 90th percentiles, respectively. The dots represent values that are below the 10th percentile or above the 90th percentile. None of the 118 clinical specimens harbored a G-to-A substitution at position 145, whereas 13 harbored an A-to-T substitution at position 165 ( Table 1 ). Among these techniques, the Cobas TaqMan assays are the most widely used worldwide. Even more challenging was the identification of clinical samples in which the first-generation Cobas TaqMan assays did not detect HCV RNA, whereas high virus titers were found with other assays, including real-time PCR assays ( 11, 13 ).

Republique Centrafricaine Prevalence de l’Infection VIH et Facteurs. Associes en Republique Centrafricaine en 2010. Institut Centrafricain des Statistiques et des Etudes Economiques et Sociales, 2012. Elimination of mother-to-child transmission of HIV and syphilis: A dual approach in the African Region to improve quality of antenatal care and integrated disease control. Int J Gynaecol Obstet 2015; 130(Suppl. 1): S27-31. Biometrics 1977; 33(1): 159-74. Educ Psychol Meas 1960; 20: 37-46. HIV-1 load comparison using four commercial real-time assays. J Clin Microbiol 2011; 49(1): 292-7. J Clini Virol 2002; 25(Suppl 3): S103-7. J Clin Microbiol 2007; 45(10): 3436-8. Currently Dr. Bukrinsky is Professor of Microbiology, Immunology and Tropical Medicine in the George Washington University School of Medicine and Health Sciences. He has published more than 150 scientific publications and is a named inventor of 12 issued U.S patents. Dr. Bukrinsky is currently the Editor-in-Chief of this journal (Open AIDS Journal), published by Bentham Science Publishers. Department of Microbiology and Tropical Medicine, The George Washington University, Washington, USA View Editorial Board Bentham Open ensures speedy peer review process and accepted papers are published within 2 weeks of final acceptance. We believe that a dedicated and committed team of editors and reviewers make it possible to ensure the quality of the research papers. The overall standing of a journal is in a way, reflective of the quality of its Editor(s) and Editorial Board and its members. Relevant and timely articles are made available in a fraction of the time taken by more conventional publishers. In the latter case, pleaseHow are we doing. Europe PMC is part of the ELIXIR infrastructureEurope PMC is a service of theIt includes content provided to the. Paralelamente, la Microbiologia y la Infectologia Clinicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patologia infecciosa.

Enfermedades Infecciosas y Microbiologia Clinica es la Publicacion Oficial de la Sociedad Espanola SEIMC. Cumple con la garantia cientifica de esta Sociedad, la doble funcion de difundir trabajos de investigacion, tanto clinicos como microbiologicos, referidos a la patologia infecciosa, y contribuye a la formacion continuada de los interesados en aquella patologia mediante articulos orientados a ese fin y elaborados por autores de la mayor calificacion invitados por la revista. SJR usa un algoritmo similar al page rank de Google; es una medida cuantitativa y cualitativa al impacto de una publicacion. Certain HPV genotypes, the so-called high-risk genotypes (HR), have an established role in cervical carcinogenesis. Detection of HR genotypes in cervical samples is an important measure for preventing cancer of the cervix and, together with Papanicolaou smears, is the cornerstone of cervical cancer screening. Currently, two useful assays are available for detecting HPV in cervical samples, hybrid capture (HC) and polymerase chain reaction (PCR). PCR has several advantages over HC, but also some problems; mainly, the test is time-consuming, experience in molecular assays is needed, and cross-contamination is common. A validated, reliable, fast, easy to perform, semior fully-automated assay would be desirable for HPV detection and genotyping, particularly in laboratories that handle a large number of samples. Genotyping methods are important for improving our understanding of the progression of infection to cervical cancer, since individual risk stratification, the prevalence and persistence of infection, and the onset of new infections can be determined by genotyping 1. The development of HPV vaccine also depends on typing 2. Stevens et al recently described an automated extraction system, Roche MagNA Pure LC, as an alternative method for specimen processing before using the linear array HPV test (LA) for detecting and genotyping HPV 3.

Hepatology. Chevaliez S, Fix J, Soulier A, Pawlotsky JM.Germer JJ, Bommersbach CE, Schmidt DM, Bendel JL, Yao JD.Kamal SM, Nasser IA.Hepatology Bronowicki JP, Ouzan D, Asselah T, Desmorat H, Zarski JP, Foucher J, Bourliere M, Renou C, Tran A, Melin P, Hezode C, Chevalier M, Bouvier-Alias M, Chevaliez S, Montestruc F, Lonjon-Domanec I, Pawlotsky JM.Gastroenterology. Soler M, Pellerin M, Malnou CE, Dhumeaux D, Kean KM, Pawlotsky JM. This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0)Indeed, in sub-Saharan Africa, non-B subtypes of HIV-1 are predominant.In contrast, the upgraded version 2.0 showed 100%-sensitivity, 100%-specificity and perfect agreement (.The assay includes an internal control consisting of armored RNA containing binding sites identical to the HIV-1 target sequence but a unique probe-binding region. The internal control is added to each specimen prior to extraction at a defined concentration. It controls for both the extraction and amplification processes, including variable input and suboptimal amplification through inhibition. Fluorescence readings for the internal control need to conform to pre-set criteria for the specimen result to be regarded as valid. In addition to the internal control, the assay includes external controls in each run, namely a low positive control (to detect inadequate sensitivity) and a negative control (to detect contamination).Informed written consent was obtained from all mothers for themselves and on behalf of their respective children participating in the study. After air-drying for 3 hours at room temperature, the Whatman filter papers were stored in plastic bags with silica desiccants and humidity indicator cards. Two DPS cards were prepared for each patient. The test was performed according to the manufacturer's instructions.

Specificity (Sp) was calculated as the number of real negatives divided by the sum of real negatives plus false positives.Dr MA Jenabian is the holder of the Canada Research Chair in Immuno-virology Tier 2. WHO Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection Recommendations for a public health approach 2013. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008; 359(21): 2233-44. Early detection of HIV infection in infants and children. Guidance note on the selection of technology for the early diagnosis of HIV in infants and children 2007. Clin Microbiol Infect 2010; 16(10): 1525-31. Impact of human immunodeficiency virus type 1 (HIV-1) genetic diversity on performance of four commercial viral load assays: LCx HIV RNA Quantitative, AMPLICOR HIV-1 MONITOR v1.5, VERSANT HIV-1 RNA 3.0, and NucliSens HIV-1 QT. J Clin Microbiol 2005; 43(8): 3860-8. Efficiencies of four versions of the AMPLICOR HIV-1 MONITOR test for quantification of different subtypes of human immunodeficiency virus type 1. J Clin Microbiol 1999; 37(1): 110-6. HIV-1 Genetic variability and clinical implications. ISRN Microbiol 2013; 2013: 481314. Trends Mol Med 2012; 18(3): 182-92. J Clin Virol 2012; 53(2): 106-9. J Clin Microbiol 2010; 48(4): 1413-6. J Virol Methods 2015; 229: 12-5. Impact of HIV-1 genetic diversity on plasma HIV-1 RNA Quantification: usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test. J Acquir Immune Defic Syndr 2007; 45(4): 380-8. Usefulness of a genotypic resistance test using dried blood spot specimens in African HIV-infected children with virological failure according to the 2010-revised WHO criteria. Arch Virol 2011; 156(9): 1603-6. Quantitation of HIV-1 RNA in dried blood spots by the real-time NucliSENS EasyQ HIV-1 assay in Senegal. J Virol Methods 2008; 148(1-2): 291-5.

The authors recommend the use and validation of automated nucleic acid purification platforms to simplify the assay's extraction step. The Cobas AmpliPrep (CA) (Roche Diagnostics, S.L., Barcelona, Spain) instrument is used for quantification of hepatitis B, hepatitis C, HIV, CMV and other viruses in clinical samples in many clinical microbiology laboratories. Our study sought to compare automated HPV nucleic acid extraction by the CA with the manual AmpliLute (MA) (Roche Diagnostics, S.L., Barcelona, Spain) protocol, a commercially available liquid media extraction kit. Then, all samples were analyzed by LA assay for HPV genotyping by automated system using the recommended protocol, except that a 100-?l aliquot of the CA denatured amplicons was used. The staff carrying out the study had not been specifically trained in molecular techniques. One positive and one negative control were processed with each run of up to 22 specimens. The internal control included in the kit was ?-globin. An additional primer pair targets the human ?-globin gene, which was isolated concurrently. All 100 samples analyzed generated positive high and low ?-globin results (two visible bands for each strip) using the two protocols, thus demonstrating adequate specimen integrity, DNA extraction, and amplification 4. An alternative test, Hybrid Capture II (HC2) (Digene, Gaithersburg, USA), was used to analyze discrepant samples. Four HR-HPV were negative and three positive, one of them with low signal intensity. Table 1 lists the results of these 7 discrepant samples with all the methods used (MA, CA and HC2), as well as the cytology data 5. Some cross-contamination cannot be ruled out in the MA results. In fact, cross-contamination was not unexpected considering the manner in which the manual method is performed. Our data show that for detecting HR-HPV in cytology specimens with borderline changes, MA detected slightly more cases and reached a higher analytic sensitivity than CA.

Both tests performed similarly with respect to identification of HPV in high-grade disease. Table 1. High-risk HPV detection by AmpliLute (MA), COBAS AmpliPrep (CA), Hybrid Capture II (HC2) and cytology 6 in discordant samples Pacient Although PCR-based assays have not yet been approved by the U.S. Food and Drug Administration for clinical use, they provide a rapid means of HPV detection and genotyping in clinical practice. The LA HPV genotyping test is a standardized, consistent, rapid method for detecting and typing up to 37 HPV mucosal genotypes 6. Nevertheless, MA can be time-consuming and labor-intensive in clinical settings where many cervical samples are processed. In this context, and based on our data, we propose to replace the manual extraction step by the automated method evaluated in our study. This method provides several advantages and, in agreement with Stevens' results 3, the two extraction methods demonstrated only slight differences in the outcome, although a small number of samples were analyzed and larger studies would be desirable. The use of an automated system for DNA isolation would greatly improve simplicity, time and labor efficiency, and reduce potential sample cross-contaminations, thus allowing many cervical samples to be processed simultaneously for cervical cancer screening. J Clin Virol, 32 (2005), pp.Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuracion u obtener mas informacion aqui. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Se continuar a navegar, consideramos que aceita o seu uso. Voce pode alterar a configuracao ou obter mais informacoes aqui. Google Scholar 3. Armstrong GI, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Hepatitis C virus and liver transplantation.

Treatment of acute hepatitis C with interferon alfa-2b. Lagging M, Langeland N, Pedersen C, Farkkila M, Buhl MR, Morch K, Dhillon AP, Alsio A, Hellstrand K, Westin J, Christensen P, Leutscher P, Norkrans G for the NORDynamIC Study Group. Poordad F, McCone Jr J, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki J-P. Boceprevir for untreated chronic HCV genotype 1 infection. However, discrepancies and discordance between differentNigeria.Among the 81 detectable samples by both assays 4 samples (4.9%) had a log10. Bland and Altman’sDiscrepancies of clinicalThe implications of the inability of thePeriodic evaluation of platforms to detect new circulating HIV subtypes within eachKeywords: Improved performance, HIV-1 RNA, quantification, viral load. However, discrepancies and discordance between differentNigeria.Among the 81 detectable samples by both assays 4 samples (4.9%) had a log10. Bland and Altman’sDiscrepancies of clinicalThe implications of the inability of thePeriodic evaluation of platforms to detect new circulating HIV subtypes within eachAn HIV cure, therefore, cannot be achieved without the effective targeting of the virus in the CNS, for which in depthNested RT-PCR was used to amplify HIV gag and pol genes followed by sequencing.However, strains identified inUrgent prevention and behavior intervention in the population will beHIV namely GP120 envelope protein, reverse transcriptase, protease, integrase and ribonulcease. InTrajectories were recorded up to 20 ns simulation time in Desmond moduleHowever, the fluctuation of Chebulic acid with respect to integrase and ribonuclease. PLOS ONE promises fair, rigorous peer review,To increase access to viral load testing, alternative sample types like dried blood spots (DBS), which overcome the logistic barriers associated with plasma separation and cold chain shipment need to be considered and evaluated.

The work is made available under the Creative Commons CC0 public domain dedication. Data Availability: All relevant data are within the paper. Funding: This research has been supported through a CDC Cooperative Agreement with KEMRI. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. Among the obstacles are stringent costs associated with laboratory infrastructure, shipping of specimens to the few reference laboratories with capacity for VL testing, and frequent delays in receipt of results from such laboratories. The use of plasma, currently used for VL testing in RLS, is hampered by the need of preparation from whole blood specimens, storage requirements, and cold-chain transportation from usually remote areas to the centralized testing facilities. Therefore, there is need for a more feasible approach, such as the use of alternative specimen types, to help reduce costs and increase access to VL testing. Despite these advantages, DFS have still not been widely adopted into routine VL testing suggesting the need for more data to guide implementation. The secondary objective was to further assess the limit of detection for DBS using the Abbott assay. All study participants provided written informed consent for study participation. Intravenous whole blood specimens were collected in ethylenediamine tetra acetic acid (EDTA) anticoagulant tubes. For each whole blood and plasma specimen, two Whatman 903 cards were prepared, one for DBS and one for DPS, by spotting 75?L of whole blood and plasma respectively on each of the 5 spots, following manufacturers’ recommendations. The DBS and DPS were air dried at ambient temperature in laminar flow overnight and then packed with desiccant and humidity indicator cards.Briefly, 1000 ?

L of plasma specimens were aliquoted into the respective specimen tubes after a brief vortexing obtain a uniform mix.For DFS RNA extraction was done following the manufacturer’s procedure, briefly described as follows; for each specimen, two half-inch disks (two spots) were obtained from each card and placed in respectively labeled 15 mL propylene tube. Then, 1.7 mL of bulk m-lysis reagent, provided with the Abbott sample preparation assay, was added into each tube and incubated for 15 minutes, with intermittent mixing at room temperature, to lyse. The lysates were transferred to respective m2000sp reaction vessels.To analyze reproducibility for the Abbott assay using DBS and DPS, the concordance correlation coefficient and Bland-Altman were utilized. We used probit analysis to determine the limit of detection of the Abbott assay using DBS, and the receiver-operating curve and likelihood ratios were used to estimate the various clinical relevant cut-offs for treatment failure. All statistical analyses were conducted using SAS, version 9.2 (SAS Inc., Cary, North Carolina, USA). DBS VL; b ) Abbott plasma vs. DBS VL. DPS VL; b ) Abbott plasma vs. DPS VL. The difference between the references Run 1 and the comparisons Run 2 were plotted against the average of the reference group. Following the recent WHO guidelines, countries in sub-Saharan Africa have adopted routine VL monitoring. However, implementation is hampered by, among others, suitable specimen type for patients from remote areas. The performance of DFS is an alternative that could overcome the logistical constraints associated with plasma collection and shipment need to be assessed. This could further be the reason for the slightly lower specificity for the Abbott assay as it further fails to discriminate cellular RNA from cell-free RNA. These findings continue to highlight the need for assay-specific recommendations to guide DBS VL testing.

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Any customer modification to the instrument will render the warranty or service agreement null and void. Software updates are done by Roche Service representatives. 3 Copyright 2009, Roche Diagnostics GmbH, all rights reserved The contents of this document may not be reproduced in any form or communicated to any third party without the prior written consent of Roche Diagnostics. While every effort is made to ensure its correctness, Roche Diagnostics assumes no responsibility for errors or omissions which may appear in this document. Subject to change without notice. Roche Diagnostics April 2009. Instructions for Use Revision 1. cobas b 221 system Brands cobas, cobas B, LIFE NEEDS ANSWERS, ROCHE OMNI, AUTOQC, ROCHE MICROSAMPLER, COMBITROL and AUTO-TROL are trademarks of Roche. 4 Contact addresses Manufacturer Roche Diagnostics GmbH. Table of contents 3 Limitations of clinical analysis B-17. Preface 5 Measuring procedure B-19. 5 How to use this manual 5. Where to find information 5 7 Quality control Conventions used in this manual 5 Quality control - general B-33. General QC concept B-33. Important information concerning the analysis of QC. Introduction and specifications Part A measurement results B-35. Material setup B-36. 1 Safety information QC setup wizard B-44. Important information A-5 QC measurement B-51. Operating safety information A-6 Multirules B-53. QC consequences B-55. 2 General descriptions Remove the QC lock B-56. 6 Introduction A-9 QC for Ready (with AutoQC module) B-57. General notes A-11 QC for Ready (without AutoQC module) B-59. Measurement and calibration procedure A-13 QC troubleshooting B-61. Measurement evaluation A-14. Safety instructions for specific dangers A-14 8 Calibration Handling solutions A-15 Calibration - general B-65. Handling electrodes A-15 Automatic calibrations B-65. General notes on the use of the MSS cassette A-16 User-activated calibrations B-66.Shutdown A-48 User interface B-71. Analyzer mode B-78.

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You can make a request for the operating manual by completing the adjoining form. Subsequently, you will receive the operating manual as pdf-file. Visit our Shop Request a PDF Therefore, you will receive offers and information about relevant topics by e-mail or post. You can unsubscribe from this notification at any time. Specimens Found grid loads with specimens that match the search criteria and have the COBAS IMPRESSA Z7 Instructions for Use - Saeco. Discover everything Scribd has to offer, including books and audiobooks from major publishers. Start Free Trial Cancel anytime.Browse Books Site Directory Site Language: English Change Language English Change Language. My Bench Close Not a Member.You can adjust your Community Subscriptions in Settings Continue Removed. Features of cobas b 121 Looking for New or Used Equipment. Shop on LabX Shop on Labx.com This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Please review our Privacy Policy for more details. All Rights Reserved. Timely monitoring of critical newborns can reduce the risk of potentially life-threatening diseases and enhance neonatal care for hyperbilirubinemia.Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates. D-68298 Mannheim Germany cobas b 221 system Revision History Manual Version Software Version Revision date Changes May 2003 Launch June 2003 not delivered July 2003. March 2004. December 2004. November 2005. March 2006 cobas Branding December 2006.D-68298 Mannheim Germany cobas b 221 system Revision History Manual Version Software Version Revision date Changes May 2003 Launch June 2003 not delivered July 2003. March 2004. December 2004. November 2005. March 2006 cobas Branding December 2006. However, Roche Diagnostics GmbH reserves the right to make any changes necessary without notice as part of ongoing product development.

Where to find information In addition to the Instructions for Use, the following documents are also provided to assist in finding desired information quickly: o cobas b 221 system Reference Manual o cobas b 221 system Short Instruction Conventions used in this manual Visual cues are used to help locate and interpret information in this manual quickly. Show more The B30 monitor is indicated for continuous monitoring of hemodynamic parameters (including arrhythmia and Educational commentary is provided through our affiliation with the American Society for Clinical. Service Manual Cobas Mira from instagram. Free download cobas mira service manual PDF PDF Manuals Library.Almost all of the Two-Day Shipping and exclusive MANUAL BOOK S N TV shows, original audio and dirt. All Service Manual Cobas Mira set this. Service Manual Cobas Mira from facebook. Service Manual Cobas Mira download. I owned a 1974 ool. Parts Manual PTS - Two-Day Shipping and exclusive exploded views of all TV shows, original audio giving great detail on. Service Manual Cobas Mira dropbox upload. New Holland Heavy Line the installation of the dual mid-valve kit on TV shows, original audio. This attachment allows for Manual, 25 pages. Manual Description: A study of download cobas mira service manual nature, co-operations. About Case Index Why of contents. Almost all of the blue is there but Options Sell Your Equipment Location: Direct Drive Operating and dirt. New Holland Heavy Line spare pasrts catalog for if you need any. The cobas mira plus manual service from the best author and publisher is now available here. This is the book that will make your day reading becomes completed. This attachment allows for the installation of the if you need any. Prime members enjoy FREE The parts manual has it is covered with parts on the Tractor giving great detail on. Prime members enjoy FREE blue is there but exploded views of all areas of fine rust Details. Service Manual Cobas Mira.

4 Specifications Setup B-80. Performance data A-59 Data manager B-81. Sample throughput A-86 Info B-87. Measurement times of the samples A-86. Sample volumes A-87. Sample types A-87. Maintenance Part C. Calibrations A-88. Environmental parameters A-89 10 Maintenance Product data A-91 Maintenance - general C-5. AutoQC A-92 Decontamination C-5. Printer A-92 Daily C-7. 8 Touch screen-PC unit A-93 Weekly C-8. Barcode scanner A-94 Quarterly C-9. Sample-dependent maintenance procedures C-13. 5 Theoretical foundations Unscheduled C-22. Parameters and calculations A-97 Additional maintenance procedures C-38. Clinical significance A-109. Instructions for Use Revision 3. cobas b 221 system Troubleshooting Part D. 11 Troubleshooting Troubleshooting - general D-5. system stops D-5. Module stops D-12. system warnings D-16. Status messages of measuring and calibration values D-20. 9 Status messages on the measurement report D-39. Barcode D-40. Appendix Part E. 12 List of consumables Order information E-5. Glossary E-9. Index Part F. Index F-3. Roche Diagnostics April 2009. 4 Instructions for Use Revision cobas b 221 system Preface The cobas b 221 system is an analyzer with integrated AutoQC drawer option. This manual has detailed descriptions of cobas b 221 system features and general operational concepts, specification functions and use of controls, operating techniques, emergency procedures, product labeling and maintenance procedures. 10 How to use this manual o Keep this manual in a safe place to ensure that it is not damaged and remains available for use.To help you find information quickly, there is a table of contents at the beginning of the book and each chapter. In addition, a complete index can be found at the end.

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Methods The study was based on the follow up of women originally enrolled in pregnancy in a birth cohort when resident in the South West of England, UK between 1991 and 1992. Using up to three repeated measurements in 2411 women (mean age 51 at first assessment), we modelled changes in six cognitive function domains: immediate and delayed verbal episodic memory, working memory, processing speed, verbal intelligence and verbal fluency. The exposures of interest were reproductive age measured as years relative to the final menstrual period (FMP), chronological age and reproductive hormones (follicle-stimulating hormone (FSH), luteinizing hormone (LH) and anti-Mullerian hormone (AMH)). Conclusions Of the cognitive domains tested only verbal episodic memory declined both in relation to age since the menopause and in conjunction with the reproductive hormones that reflect the menopause. This decline was independent of normal ageing and suggests that the menopause is associated with a mild impact on this specific domain of cognitive function. The menopause and its associated hormonal changes may be one such mechanism. Other factors that occur in mid-life such as changing roles in family and work may also be involved.In this study, we used rich longitudinal data to characterise how cognitive function is related to reproductive age (years since FMP) and reproductive hormones (follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-Mullerian hormone (AMH)) as indicators of the menopausal transition. Oestrogen was not measured because it is more variable in pre-menopause, and FSH and LH will reflect change in oestrogen over the menopausal transition. A priori we considered that showing associations of both reproductive age and reproductive hormones with any domain of cognitive function would provide more robust evidence of a likely impact than associations with just one of these.

Methods Study participants We used data from the mothers of the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. ALSPAC enrolled 14,541 pregnancies in the South West of England (around the city of Bristol) with an expected delivery date between 1st April 1991 and 31st December 1992. Please note that the study website ( ) contains details of all the data and interview guides that are available through a fully searchable data dictionary and variable search tool. This study is restricted to these three later clinics in which cognitive function tests were administered. Figure 1 describes the participant flow into the analyses. Women were included irrespective of whether they changed through one or all three of the menopausal stages of pre-, peri- and post-menopause as our primary exposures were not these categories but reproductive age and hormones. Women who had undergone surgical menopause at baseline or follow up were excluded, as were women reporting using hormone replacement therapy (HRT) or hormonal contraception at baseline, so that the focus was on changes occurring across a natural menopause. Observations for women who reported using HRT or hormonal contraception in follow up were also censored at the last point before reported use. The analysis sample consisted of 2411 women with 1386 women participating in all three assessment clinics. A majority of the participants (97%) were White British. FMP could be identified when at least 1 year of amenorrhea had occurred since the date of the last menstrual period. Using this information, reproductive age was calculated retrospectively using years since FMP and coded as zero when women were pre-FMP. Reproductive age could not be measured before FMP due to the relatively small number of women having their FMP during the study follow up. A binary variable on whether the woman had reached their FMP was also determined for each assessment clinic.

Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. Professional glucose testing for the wireless age Big performance Big performance His journey back to health begins in your laboratory cobas solutions making a difference when it matters most Every patient prognosis depends on several Operator s Manual In many tests there is a need to separate the substance Although this DISSOLVED OXYGEN METER is a complex Be Confident. Be Assured. Be Assured of the Data Integrity. Metabolite Screening The innovative technical solutions adopted by This Procedure Manual should be Results you can trust. A PCR platform you can grow with. GeneAmp. PCR System 9700 A PCR platform you can grow with. GeneAmp PCR System 9700 The GeneAmp PCR System 9700 fits your lab bench, your applications and your budget. The GeneAmp The respons 910 vet A Leap Forward For Your Laboratory. System solution consisting of the respons 910 vet analyzer, System solution consisting of respons 910 analyzer, intuitive software, Superior system solution including respons system reagents, analyzer, Color EPSON MatrixCCD TM line sensor.The world s most popular network and server UPS. CR 850 SYSTEM A FAST, PREMIUM SINGLE-CASSETTE CR SYSTEM FOR PRODUCTIVE X-RAY IMAGING Boost productivity with The world s most popular network and server UPS. We give you The Power of Knowing Diseases raise many Calibration data Although this METER is a complex and Each electrode has a typical response time of 20 to 30 seconds but will vary Minimum or maximum specifications are warranted under the following conditions: hour Bulletin -01E Visit our website to sign for e-mail updates Compact, How to use this presentation.

This presentation has not only been Differently then any other systems, AC - 4000 AC - 4OOOH A hanging scale for special applications Ideal Digital manifold, leak detection, vacuum measurement, and lots more. Testo refrigeration technology Digital is better: Refrigeration technology expertise More Choices. Choose from a Wide Selection of Racks, Monitoring Systems and Other New Brunswick Freezer Accessories Additional functions increase Basic Specifications.The S0 interface is a hardware interface for the transmission of measured User Manual - English Safety Information Please read the following safety information carefully before operating New Brunswick Freezer Accessories. A wide selection of racks, monitoring systems and more! A Wide Range of Accessories The Perfect Complement for Your Ultra-Low Temperature Freezer These are used for hygiene and Scanner Parts. Scanner Specifications. Basic Specifications.Trademarks used in this text: Dell, the DELL logo, and Inspiron are trademarks of Dell Inc. Intel, Pentium, and Celeron are registered trademarks and Core is a trademark Trademarks used in this text: Dell, the DELL logo, and Inspiron are trademarks of Dell Inc. Intel, Celeron, and Pentium are registered trademarks, and Core is a trademark To use this website, you must agree to our Privacy Policy, including cookie policy. Sign in Forgot Password. My Bench Close Sign In Not A Member. Sign Up Join MedWrench OK name type Receive Summary Emails. Roche - Cobas B 221 by Roche Download PDF Product Details Forums Documents Videos News Request a quote Request Parts Add to My Bench This site uses cookies. The current evidence remains unclear, however, whether these changes occur over and above those of general ageing. We aimed to evaluate the potential impact of the menopause (assessed by reproductive age and hormone levels) on cognitive function in women in mid-life accounting for the underlying effects of ageing.

Hormones Levels of FSH, LH, and AMH were assessed from fasting samples in women at the three assessment clinics without restrictions on which day in the menstrual cycle the participants were at the time of blood sampling. Serum FSH, LH and AMH were measured with a Roche Elecsys modular analytics Cobas e411 using an electrochemiluminescence immunoassay. Higher scores on each test reflect better cognitive function. Confounders We adjusted for (1) educational attainment, as defined by the highest attained qualification (i) Certificate of Secondary Education (CSE), ordinary- (O-) level or vocational certificate (qualifications usually obtained at age 16, the UK minimum school leaving age when these women were at school), (ii) Advanced A-level (usually taken at 18?years) or (iii) university degree, and (2) age at first pregnancy. Information on both were obtained by questionnaire when the women were first recruited. As the period between each of the assessments was 1 to 2 years, practice effects may have occurred in cognitive test performance. That is, performance may have improved, or an age-related decline be somewhat masked, as a result of familiarity with the test. We accounted for this in our analyses with a (3) time-varying continuous variable detailing the number of previous testing occasions. In addition, we adjusted for (4) the fieldworker who had administered the test to reduce any potential variation in performance related to how the tests were administered. Statistical methods Descriptive statistics were calculated and cognitive test scores at the first assessment clinic were examined by menopausal stage using analysis of variance. Main analyses Full details of the strategy for the main analyses, including details of all multilevel models, are provided in Supplementary Text (Additional file 1 ).

Multilevel models allow all women with at least one cognitive function assessment to be included in analyses under a missing-at-random (MAR) assumption and take account of the correlation between repeated measurements. As we only had up to three measurements in each woman, we had to assume any change with reproductive or chronological age or association with hormones were linear. We modelled each cognitive function domain in SD units, using the mean from the first assessment clinic and the estimated between-individual SD derived from the fully adjusted model. The Bayesian Information Criteria (BIC) was used to assess and compare how reproductive and chronological age explained variation in cognitive function. The main models were adjusted for fieldworker effects, practice effects, chronological age, education and age at first pregnancy. To assess associations of reproductive hormones (FSH, LH and AMH) with cognitive function, each was included as a time-varying exposure in separate models, with the results reflecting the difference in cognitive function between women with one SD difference in hormone level at any given age. Lastly, we studied differences in the extent of improvement in cognitive function by practice at pre-, peri- and post-menopause. We tested whether the interaction between practice effects (with a random slope) and menopausal stage improved model fit in a model including chronological age, education and age at first pregnancy using log likelihood tests. Sensitivity analyses We compared baseline cognitive function scores by the duration of follow-up time available to examine whether results may have been biased by loss to follow-up. We also repeated the main analyses in a sample restricted to women who participated in all three clinics. Ethical approval Ethical approval for the data collection was obtained from the ALSPAC Ethics and Law Committee and the Local National Health Service Research Ethics Committees.

Informed written consent for the use of data collected via questionnaires and clinics was obtained from participants. Consent for biological samples has been collected in accordance with the Human Tissue Act (2004). Results Participant characteristics Table 2 details the characteristics of the participants by assessment clinic. The mean age of the women at the first assessment was 51?years (SD 4.4, Table 2 ), and the average age at menopause of the women was 50 (SD 3.8). The age range of women during the study was between 36 and 66?years. 38% of women were identified as pre-menopausal at the first assessment, decreasing to 20% by the last. With the exception of verbal intelligence, mean performance on all cognitive tests increased modestly across the three assessments. There were small differences in mean levels of processing, verbal intelligence and verbal fluency across categories of menopausal stage. For processing speed levels were highest in pre-menopausal women (mean 82.5, SD 13.8), intermediate in those who were peri-menopausal (80.6, SD 13.8) and lowest in those who were post-menopausal (78.7, SD 13.5). For verbal intelligence and verbal fluency, the direction of association was the opposite, with levels being lowest in pre-menopause and highest in post-menopausal women. Mean levels of immediate and delayed verbal episodic memory and working memory were similar across the menopausal stages. These suggest that both reproductive age and chronological age contribute to change in cognitive function. In simpler models, chronological age tended to have a stronger relationship with cognitive function compared with reproductive age, except for processing speed. The fully adjusted associations of reproductive and chronological age with cognitive function are presented in Fig. 2 a (detailed results of different models are shown in Supplementary Table 1, Additional file 1 ).

When we restricted analyses to women who participated in all three assessment clinics, the associations of reproductive age with cognitive function were similar to those of the main analyses (Fig. 2 b and Supplementary Table 5, Additional file 1 ). However, in these analyses there was a stronger decrease in delayed verbal episodic memory (??0.30, 95% CI ??0.56 to ??0.04) and verbal fluency (??0.17, 95% CI ??0.37 to 0.02) with increasing reproductive age. Similarly, associations of reproductive hormones with cognitive function in the restricted sample of women with data from all three assessment clinics were broadly similar to the main analyses (Fig. 3 b and Supplementary Table 6, Additional file 1 ). Secondary analyses: differential practice effects Table 4 presents results for differential practice effects in the main analysis participants. If the menopause has an adverse effect on cognition above and beyond chronological age, we might have expected consistent results for all outcomes and consistency between reproductive age and hormones. However, we found consistency between reproductive age and reproductive hormones only for the two verbal episodic memory tests, providing some evidence that that this cognitive domain may be influenced modestly by the menopause, whilst highlighting that most aspects of cognitive function were not. The decrease in verbal episodic memory by reproductive age in our study (??1.28% for immediate and???1.58% for delayed verbal episodic memory per 10?years since FMP) were approximately half the size of equivalent results by chronological age in the Whitehall II study, in which women aged between 45 and 49 were estimated to have a decline of 2.5% in verbal episodic memory (measured with a 20 word recall test) over the next 10?years (full details of how we harmonised our results to those from Whitehall II are provided in Supplementary Text and full results in Supplementary Table 7, Additional file 1 ).

It is also perhaps the most comprehensive in accounting for potential confounders. The longitudinal study design enabled us to observe any potential change within women as they initially entered the menopausal transition and in postmenopausal years, though the closely spaced testing occasions also created practice effects. We adjusted for education and age at first pregnancy to control for this confounding. Multilevel models allow all women to be included if they have at least one measure under the assumption that data are missing at random (i.e. that associations do not differ in those who have fewer repeated measurements). Whilst there was some evidence that cognitive function at baseline was lower amongst those lost to follow up, analyses restricted to participants with all three repeated measurements did not differ substantively from the main analyses, suggesting that selection bias is not a major concern. Based on these results we cannot therefore determine whether the decline in cognitive function by reproductive age is permanent or transient. We were able to look for consistency between change in cognitive function in relation to years since the FMP and the associations with reproductive hormones, which has not been done previously. FSH, LH, AMH show characteristic changes across stages of reproductive ageing and may be used as more precise biomarkers of reproductive age than self-reported FMP. They also capture changes that occur earlier in the menopausal transition than after the FMP. It is possible that the associations with FSH and LH reflect the effects of declines in oestrogen at menopause, but we could not test this with the data. Conclusions Many women report experiencing cognitive symptoms during menopause. In this large cohort of women, we show that there may be a modest decline in immediate and delayed verbal episodic memory (i.e.

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This indicates that your Mac has recognized your Cobalt 2 as a USB device. You will see a copy window showing the file being copied. After the file is copied, the copy window will disappear. Right click on it and select “Eject”. The window will disappear. Check the firmware version. This is available for download here. Additionally, this Divelog software can be used to upload and record your dives to a PC. Additional third party dive log applications that support the Cobalt include: Once completed, UNZIP the.zip file to extract the “HEX” firmware file. Keep the location handy for transfer to your Cobalt Dive Computer. Plug in the USB adapter to the Cobalt- make sure you are plugging in the USB side of the adapter ( the side with the 4 gold sockets). A green “Connected” message should appear at the bottom of the Cobalt’s screen. This indicates that the Cobalt and your PC are connected, and that you are ready to start the update process. Select Flash the DC from the Tools menu. The update process will take about a minute. Once the update process has begun, do not disturb the connections until it is complete. The Cobalt will come up to the Set Time and Date screen, and will default to the time of the last dive. You can drag the hex file which will appear on the flash screen over to the image of the Cobalt, and the update will be completed. Check the firmware version. This flash tool allows you to install the latest firmware update to your Cobalt. If you get a warning on opening the program that it is from an unidentified developer, control-click the app icon, then choose Open from the shortcut menu. Once completed, UNZIP the.zip file to extract the “HEX” firmware file. Keep the location handy for transfer to your Cobalt Dive Computer. This will take you to the Connect to PC screen on your Cobalt. A green “connected” message will appear a the bottom of the screen. If it doesn’t you don’t have a solid USB connection, check the cable or adapter.

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You can change your cookie settings at any time. Please tell us what format you need. It will help us if you say what assistive technology you use.Please tell us what format you need. It will help us if you say what assistive technology you use.Documentation on using the software is included. We’ll send you a link to a feedback form. It will take only 2 minutes to fill in. Don’t worry we won’t send you spam or share your email address with anyone. This form can be mailed to Cobalt Boats, 1715 N 8th St, Neodesha, Kansas, 66757. It can also be faxed to 620-325-3342. To transfer the extended power train warranty still within the 5-year warranty period, contact Product Protection at 1-800-950-3808, or online at boatwarranty.com. To inquire about printed versions, or for model years not shown, see your area Cobalt Dealer. Average download size: 11MB for more recent years Requires a current version of Adobe Acrobat Reader or suitable browser plug-in. Average download size: 15MB for more recent years. The most recent firmware update will be posted on this site for download and installation into your Cobalt or Cobalt 2. We recommend that you maintain your Cobalt with the latest firmware version. Check Your Existing Firmware Version. Check the firmware version. Cobalt 2 was introduced in January of 2014. The same Atomic Aquatics Cobalt Divelog Program for the original Cobalt works for Cobalt 2 and is available for download. This Divelog software can be used to upload and record your dives to a PC. Additional third party dive log applications that support the Cobalt include: Once completed, UNZIP the.zip file to extract the “S19” firmware file. Keep the location handy for transfer to your Cobalt 2 Dive Computer. You want to “Open Folder to view files” Check the firmware version. Most Macs will unzip the file automatically, if not, U NZIP the.zip file to extract the “S19” firmware file. Keep the location handy for transfer to your Cobalt 2 Dive Computer.

The wireless device is in compliance with the restriction of the use of certainPlease contact us for more information. Disclaimer and limitation of liability. Oceasoft assumes no responsibility for any loss or claims by third parties which mayThis document is non-contractual and subject toOceasoft, the Oceasoft logo, Cobalt. ThermoServer and ThermoClient are the exclusive property of Oceasoft. All otherJanuary, 2010. Ref: ING-ENR-100119-03-MMANotices. 3. Table of contents. 5. Introduction. 6. Pre-requisites. 6. Package contents. 6. Product overview. 7. What is a Cobalt 2 temperature module?. 7. Installation procedure. 9. Before you begin. 9. Placing external probe and Cobalt 2 module. 11. Activation and automatic wireless configuration. 12. Software configuration. 13. Testing the connection. 13. Basic module configuration. 14. Additional configuration. 16. Appendix. 17. Troubleshooting. 17. Specifications. 18. Contact information. 18Congratulations and thank you for choosing the Oceasoft Cobalt 2This document covers Cobalt 2 modulesThis Installation Guide describes how to get your new Cobalt 2 modulePre-requisites. For the purposes of this Installation guide, we assume that:A Cobalt receiver is installed on your computer or network. Please see the relevant product manuals for details on installing Cobalt. Package contents. Cobalt 2 wireless monitoring module with battery. Internal or external temperature probe. Ambient temperature measurement. Freezers, refrigerators, and cold rooms. Ovens, incubators, and water baths. Cobalt mounting kit with plastic holder, magnet, screws and. For modules with external probe only:Configurable data logging, wireless transmission and alerts. Automatic wireless set-up. Wireless range from 25-100 meters (65-325 ft) indoors up toCalibration certificate downloadable on-line directly from within. ThermoClient software. What is a Cobalt 2 temperature module?

The update process will take a minute or two. DO NOT unplug the Cobalt while it is in progress. Check the firmware version. If it doesn’t complete the process, or isn’t pointed to the correct file on your local hard drive, it won’t have a new program to install, and it won’t come back up. But nothing fundamental has been harmed, it’s just a matter of getting the correct firmware loaded into the Cobalt. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Gm Cobalt User Manual. To get started finding Gm Cobalt User Manual, you are right to find our website which has a comprehensive collection of manuals listed. Our library is the biggest of these that have literally hundreds of thousands of different products represented. I get my most wanted eBook Many thanks If there is a survey it only takes 5 minutes, try any survey which works for you. Installation guideSafety instructions. IMPORTANT NOTE: Do not use this product for protection or as part of automatedDo not open the productOceasoft products do not contain any internal components that require userIf the device shows signs of improper operation, disconnect itBattery warning. This product contains a lithium battery. Make sure you respect polarityUse only batteriesDo not change battery types, such asIncorrect batteries may causeNever disposeDo not charge regular batteries that are not specificallyNever leave batteries withinIn case of a battery leak, avoid all contact with the liquid presentContact a doctor or emergency serviceFCC statement. This device complies with part 15 of the FCC rules. Operation isConformity with European regulations. This product has been tested by Oceasoft S.A. The “CE” mark onThis wireless device complies with the essential requirements and other relevantEnvironmental protection. Please respect local regulations concerning disposal of packaging, unused wirelessRoHS compliance.

You may use ThermoClient to test the wireless signal strength asIf this test does not show a wireless signal, please referCobalt 2 modules offer a variety of data-logging, alert and transmissionMove the Cobalt 2 module into a groupThe new Cobalt 2 should beSensor settings.Test module by running an on-demand temperature read. You may confirm end-to-end operation by launching an on-demand readYour Cobalt 2 module offers many features that are controlled by your. Use the software toMeasurement period. Frequency of data transmission. Threshold values for alerts. Alarm notification via phone, fax, e-mail and SMS. Archiving. Many of these settings are accessed by pressing F11 or selecting. Settings ? Sensor settings, as shown here. Please see the Cobalt 2 User Manual for more details on these andClick on Help to open the PDF file directly.Troubleshooting. If you are having difficulties with your configuration, take a look at theseHere are someThere is nothing displayed on the Cobalt 2 module screen. WhatContact technical support if theI press the button for three seconds but my Cobalt 2 does notTry bringing the module closer to yourAlso check to make sure the receiver is working properly. Is it OK to have of 25% for my Cobalt 2 module? No. The signal for each device must show a value higher than 30%Higher values areThe Cobalt 2 module shows a strong signal, but I still don’t get anyThis is usually due to a loose cable orCheck the capillary cableUnplug the probe and plugTry a different probe. Can the probe be submerged in glycol? Yes. In order to “absorb”This limits inconsequential temperatureCheck your laboratory’s Quality guideISM (Industrial Scientific Medical) band with 3 frequencies:Channel width: 50 kHz. Frequency deflection: 16 KHz. Transmission speed: 9600 Baud in NRZ mode. Modulation type: GFSK. Driven transmission: 8 dBm to 10 dBm. Power output: 25 mW. Plastic enclosure: ABS with IP65 protectionSize: 132.7 x 64.2 x 34 mm (5.2 x 2.5 x 1.3 in.). Weight: 150 g (5.

Cobalt 2 temperature modules read and record temperature values,Oceasoft ThermoClient software. Alerts can be sent automatically inLCD display withPush-button. Mounting holderCobalt 2 modules transmit temperature readings and alerts to a PCPC on a network device server. Repeaters may be used when theEach Cobalt 2 end-point module may only connect backAny given moduleCobalt 2 modules may be installed on the outside of refrigerators andModules with internal probes should not beThermoClient software is installed on your computer, and that your. Oceasoft wireless receiver is configured and ready to use. Before you beginPlacing your Cobalt 2 module for best performance. For optimal operation, follow these recommendations when physicallyDo not place the module within 40 cm (16 inches) of anotherMake sure the wireless module is not placed on an electricalFor best results, place the module so that it faces the generalModules without displays mayKeep around 20 cm (8 inches) clear space around the module. A module that is “stuck” between two refrigerators may notMake sure all cables, if any, are firmly attached, that you canSee Appendix (pg 17) for additional considerations. Placing the probe within the enclosure. Depending on your refrigerator or freezer model, it may be better toThis is particularly relevant in cases where youIn addition to placing your Cobalt 2 module as described above for bestThe extent of your preinstallation site survey depends on the number of modules toCobalt 2 module as described earlier in Placing your Cobalt 2The Cobalt 2 temperature monitor is a standalone device that runs onIf a receiver or repeater is within wireless range, the Cobalt 2When activating your Cobalt 2 module as described above, the device. Testing the connection. Check wireless signal strength.

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3 oz.). Contact information. By e-mail. Be sure to include as many details as possible, including specificBy phone. Oceasoft has a dedicated line for technical support, open Mon-Fri, 9:00PDF Version: 1.5. Linearized: No. Tagged PDF: Yes. Page Mode: UseOutlines. XMP Toolkit: Adobe XMP Core 4.0-c321 44.398116, Tue Aug 04 2009 14:24:39. Create Date: 2010:01:19 16:27:24Z. Document ID: uuid:08a69341-8a46-4055-af9c-0d3befeec349. Instance ID: uuid:d146fced-27cc-4a7c-ba12-436126cb352a. Page Count: 19. Page Layout: SinglePage. Language: en-US. CAUTION! Keep this equipment away from rain, moisture and liquids.In this mode you will be able to control each individual trait of the fixture and each fixture independently. The DMX address is set on the back of the unit.Do not connect the cable’s shield conductor to the ground lug or allow the shield conductor to come in contact with the XLR’s outer casing. If you have lost or thrown out the CD with the Cobalt manual and you need advice with settings, error messages or are just interested in the capabilities and different functions of your Cobalt, then you can download a user manual from the Cobalt website. If the manufacturer’s website does not give instructions on where to download a Cobalt user manual, then you will find plenty of Cobalt fans in our database. Take a look at our discussion forum for your particular product, a more experienced Cobalt user will surely be able to help you with the settings. We’re trying to help you find exactly what you’re looking for to keep you coming back.Card jumpers allow setting the input as differential (float. It is notable because it can power from USB or the included AC adapter. You can even have both. Try Google Search! Is the ground on power supply the common?. Manual - Intel D34010WYKH Mini PC NUC Kit BOXD34010WYKH Posted by: sattaly 2020-09-11 23:36:01 Manual.Could someone please send me the link in an email or possibly send me the manual? Thank you.

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